The characteristic pathology of PDD is amyloid plaque deposition, neurofibrillary tangles (NFT), and massive loss of neurons. Dementia has become one of the significant public health problems in the world in recent years, with about 7.7 million new cases diagnosed every year, of which PDD accounts for a large part. The incidence rate of Parkinson’s disease (PD) has gradually increased with age, which has affected about 1% of the elderly over 60 years old. LLPS and phase transition (LLPT) of proteins and nucleic acids have become a new research direction in cell biology. Because of the occurrence of many diseases is closely related to the liquid-solid phase transition process of protein and lipid production, such as Parkinson’s disease dementia (PDD). Through kinetic and thermodynamic ways, they undergo the liquid-solid phase transition to produce a liquid condensate that can mature and solidify, forming a structure similar to amyloid fibrin, and reaching an irreversible and more stable state. Specifically, the viscosity and rigidity of these dynamic droplets increase over time. Biological macromolecules can be condensed into membrane-free condensates like liquid through liquid-liquid phase separation (LLPS). Several research results present show that phase separation generally exists in proteins, lipids, and other substances and participates in physiological and pathological processes by changing the state of substances. In the early stage, phase separation or phase transition was applied as a physical and chemical concept to explain the separation of mixed liquids, which was extended as a biological concept to study the occurrence and development of diseases. Determining the significance of LLPS in neurodegenerative diseases such as PDD will stimulate interest in research into treatments based on interference with abnormal LLPS. Therefore, we believe that LLPS can serve as one of the means to explain the pathological mechanism of PDD. By analyzing the existing literature, we propose that LLPS is the crucial mechanism causing abnormal accumulation of α-syn, tau, and other proteins in PDD, and its interaction with iron metabolism disorder is the key factor driving ferroptosis in PDD. Substances such as proteins can form droplets through liquid-liquid phase separation (LLPS) under normal physiological conditions and even undergo further liquid-solid phase transitions to form solid aggregates under disease or regulatory disorders, leading to pathological phenomena. Studies have shown that the occurrence and development of neurodegenerative diseases such as PDD are closely related to the separation of abnormal phases. However, the links and mechanisms between these factors remain unclear. The interaction of iron accumulation with α-syn and tau was further explored as an essential pathological mechanism of PDD. Now greet your caller with Tiger Lily song by setting it up as your Hello Tune on the Wynk Music App for free.The pathological features of PDD are represented by dopaminergic neuronal death and intracellular α-synuclein ( α-syn) aggregation. So, what are you waiting for? Start streaming your favourite tunes today! TIGER LILY MATCHBOOK ROMANCE OFFLINEYou can even download MP3 songs for offline listening. Songs are the best way to live the moments or reminisce the memories and thus we at Wynk strive to enhance your listening experience by providing you with high-quality MP3 songs & lyrics to express your passion or to sing it out loud. Along with it if you are looking for a podcast online to keep you motivated throughout the week, then check out the latest podcast of Podcast. With Wynk Music, you will not only enjoy your favourite MP3 songs online, but you will also have access to our hottest playlists such as English Songs, Hindi Songs, Malayalam Songs, Punjabi Songs, Tamil Songs, Telugu Songs. TIGER LILY MATCHBOOK ROMANCE MP3 SONGWynk Music brings to you Tiger Lily MP3 song from the movie/album Stories And Alibis.
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